Canadian Healthcare Technology Logo
  • Issues
    • Current Print Issue
    • Print Archive
  • Advertise
    • Publishing Schedule
    • Circulation
    • Unit Sizes and Rates
    • Mechanical Requirements
    • Electronic Advertising
    • White Papers
  • Subscribe
    • Print Edition
    • e-Messenger
    • White Papers
  • Events
  • Vendors
  • About Us

Philips

AGFA 1400x150

Petal Health

Petal Health 1400x150

Innovation

Focused U/S used safely to deliver meds to brain

September 14, 2022


U-S Parkinsons trialTORONTO – A team of researchers from Sunnybrook Health Sciences Centre and University Health Network (UHN) are the first in the world to demonstrate that focused ultrasound technology can safely be used to deliver a therapeutic to targeted brain regions in patients with Parkinson’s disease (PD). The leading-edge study has been published in “Movement Disorders”.

“Our early findings are an exciting and critical first step in less invasive direct-to-brain delivery of therapeutics to key areas of the brain important in the development and progression of Parkinson’s disease,” says Dr. Nir Lipsman, the study’s co-principal investigator and director of Sunnybrook’s Harquail Centre for Neuromodulation. “Current management strategies for Parkinson’s include medications and more invasive neurosurgery. Focused ultrasound is a less invasive, targeted approach that could change the way brain disorders are treated in the future.”

Low intensity MRI-guided focused ultrasound technology uses ultrasound waves to breach the blood-brain barrier, a layer of cells that protects the brain from toxins but can also block potentially helpful medications from getting where they need to go. The opening in the barrier, which closes within hours of the procedure, allows the therapy to pass and reach targeted brain region with millimeter accuracy.

Typically, treatments are unable to cross the blood-brain barrier because compounds are too large. In some cases, open brain surgery is required to help manage PD symptoms.

There is currently no cure for Parkinson’s, which is a common and progressive brain disorder that causes difficulties with movement and numerous disabling symptoms which dramatically impact a patient’s quality of life. Symptoms vary, and can progress at a different rate for each individual.

Study researchers investigated the delivery of an enzyme, glucocerebrosidase, to the putamen which is a key structure in the brain related to movement. Glucocerebrosidase may help to prevent buildup of the protein alpha-synuclein, a key indicator of PD that leads to unhealthy brain cells and neurodegeneration. In Parkinson’s, the enzyme can be defective and result in PD symptoms. Enzyme replacement therapy could be one approach to reduce or prevent neurodegeneration in PD.

The Phase I trial included four patients diagnosed with early-stage Parkinson’s disease with an average age of 54 years. Participants received three doses of the therapeutic and application of focused ultrasound every two weeks to the side of the brain most affected by the disease. They were followed for three- and six months.

“The Phase I trial offered a hint of potential improvement in symptoms following treatment but this requires further study. Any side effects, such as involuntary movements, were only temporary, and none were severe,” says Dr. Lorraine Kalia, co-principal investigator and a neurologist and senior scientist at the Krembil Brain Institute, part of UHN. “It is still very early in the research, but with our first-in-the-world study findings, we are making much needed progress in the development of innovative treatments for people with Parkinson’s disease.”

The Sunnybrook and UHN researchers have launched a Phase I/II clinical trial continuing the team’s investigation.

“The upcoming trial will further explore low intensity MRI-guided focused ultrasound and targeting enzyme replacement therapy to both sides of the brain. The ultimate goal is to improve the delivery of therapeutics to the brain with the hope of improved symptoms or slowed progression of Parkinson’s disease,” says Dr. Suneil Kalia, co-principal investigator and a neurosurgeon and scientist at UHN.

“There is robust data in both preclinical and clinical studies demonstrating that glucocerebrosidase replacement is a promising disease-modifying therapy in Parkinson’s disease. The next step is to better understand the biologic effects of the treatment with further research,” says Dr. Ying Meng, the study’s first author and neurosurgery resident at Sunnybrook.

A key driver of Sunnybrook’s research in focused ultrasound is philanthropic investment. This study is funded by the Focused Ultrasound Foundation, The Harquail Family, and INSIGHTEC. UHN research is supported by the Krembil Foundation and UHN Foundation.

PreviousNext

CHT print

CHT print

e-Messenger

  • Montreal General unveils advanced surgical centre
  • Infoway announces vendor innovator winners
  • NYGH moves its EHR to Oracle cloud
  • Thunder Bay hospital uses SMS for patient surveys
  • Fundraiser aims to support former CEO of AHS
More from e-Messenger

Subscribe

Subscribe

Weekly blasts are sent each month, via e-mail, to over 7,000 senior managers and executives in hospitals, clinics and health regions. Learn More

Infoway

Infoway

Zebra

Zebra

Zebra

Zebra

Advertise with us

Advertise with us

Sectra KLAS

Sectra KLAS

Stratford Group

Stratford Group

Pure Storage

Pure Storage

Medirex

Medirex

NIHI

NIHI

CHT print

CHT print

Advertise with us

Advertise with us

Sectra KLAS

Sectra KLAS

Stratford Group

Stratford Group

Pure Storage

Pure Storage

Medirex

Medirex

NIHI

NIHI

Contact Us

Canadian Healthcare Technology
1118 Centre Street, Suite 204
Thornhill, Ontario, Canada L4J 7R9
Tel: 905-709-2330
Fax: 905-709-2258
info2@canhealth.com

  • Quick Links
    • Current Print Issue
    • Print Archive
    • Events
    • Vendors
    • About Us
  • Advertise
    • Publishing Schedule
    • Circulation
    • Unit Sizes and Rates
    • Mechanical Requirements
    • Electronic Advertising
    • White Papers
  • Subscribe
    • Print Edition
    • e-Messenger
    • White Papers
  • Resources
    • White Papers
    • Writers’ Guidelines
    • Privacy Policy
  • Topics
    • Administrative Solutions
    • Clinical Solutions
    • Companies
    • Continuing Care
    • Diagnostics
    • Education & Training
  •  
    • Electronic Records
    • Government & Policy
    • Infrastructure
    • Innovation
    • People
    • Privacy and Security

© 2025 Canadian Healthcare Technology

The content of Canadian Healthcare Technology is subject to copyright. Reproduction in whole or in part without prior written permission is strictly prohibited. Send all requests for permission to Jerry Zeidenberg, Publisher.

Search Site

Error: Enter a search term

  • Issues
    • Current Print Issue
    • Print Archive
  • Advertise
    • Publishing Schedule
    • Circulation
    • Unit Sizes and Rates
    • Mechanical Requirements
    • Electronic Advertising
    • White Papers
  • Subscribe
    • Print Edition
    • e-Messenger
    • White Papers
  • Events
  • Vendors
  • About Us